Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2454858..2455528 Replicon chromosome
Accession NC_017933
Organism Cronobacter sakazakii ES15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ES15_RS11500 Protein ID WP_014729082.1
Coordinates 2455232..2455528 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ES15_RS11495 Protein ID WP_014729081.1
Coordinates 2454858..2455199 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES15_RS11470 2450209..2450745 - 537 WP_004386563.1 YniB family protein -
ES15_RS11475 2450904..2451572 + 669 WP_004386564.1 hexitol phosphatase HxpB -
ES15_RS11480 2451760..2452515 + 756 WP_014729080.1 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD -
ES15_RS11485 2452629..2453219 + 591 WP_007792738.1 metal-dependent hydrolase -
ES15_RS11490 2453354..2454745 + 1392 WP_004386567.1 L-cystine transporter -
ES15_RS11495 2454858..2455199 - 342 WP_014729081.1 HigA family addiction module antidote protein Antitoxin
ES15_RS11500 2455232..2455528 - 297 WP_014729082.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES15_RS11505 2455692..2455922 - 231 WP_014729083.1 cell division activator CedA -
ES15_RS11510 2456134..2458389 + 2256 WP_014729084.1 catalase HPII -
ES15_RS11515 2458503..2458844 - 342 WP_004387341.1 osmotically-inducible lipoprotein OsmE -
ES15_RS11520 2459087..2459914 + 828 WP_004387342.1 ammonia-dependent NAD(+) synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11437.92 Da        Isoelectric Point: 9.7873

>T27860 WP_014729082.1 NC_017933:c2455528-2455232 [Cronobacter sakazakii ES15]
MQKHIGSFRDAWLAAFFVYSTPHRNIPAEIHTTLARKFDIINAATSYRDLRSPPGNRFEALSGKLQGYSSIRVNHHYRLI
FRWVEGKAEDLYLDPHDH

Download         Length: 297 bp

>T27860 NC_017933:c2455528-2455232 [Cronobacter sakazakii ES15]
ATGCAGAAGCATATCGGCAGTTTTCGTGACGCCTGGCTGGCGGCGTTTTTCGTGTATTCGACGCCACACCGCAACATCCC
GGCGGAGATTCATACCACACTGGCGCGCAAGTTCGACATCATCAACGCAGCAACGTCATACCGCGATCTCCGCTCGCCGC
CTGGCAACCGCTTTGAGGCGCTGAGCGGTAAATTGCAGGGGTATTCATCGATTCGGGTCAACCATCACTACCGCCTGATT
TTCAGATGGGTGGAAGGCAAAGCGGAAGATCTCTATTTAGATCCGCATGATCACTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12769.76 Da        Isoelectric Point: 8.0052

>AT27860 WP_014729081.1 NC_017933:c2455199-2454858 [Cronobacter sakazakii ES15]
MKQATRKPTTAGEILVYEYLEPLGLKINEVAEMLCVHRNSVSALVNNNRKLTTDMAFRLAKAFGTSVDFWLNLQAAVDLW
EVENDMRIQEAFSRIVPAAEFIARRDAQKKAVA

Download         Length: 342 bp

>AT27860 NC_017933:c2455199-2454858 [Cronobacter sakazakii ES15]
ATGAAACAGGCAACCAGAAAGCCCACGACGGCCGGCGAGATCCTGGTGTACGAATACCTGGAGCCGCTCGGCCTTAAAAT
CAACGAGGTGGCGGAGATGCTTTGCGTCCATCGTAATAGCGTGAGCGCGCTGGTGAACAATAACCGCAAACTCACTACAG
ATATGGCGTTTCGTCTGGCAAAAGCGTTTGGAACCTCAGTTGATTTCTGGCTTAACCTGCAGGCGGCTGTCGACCTGTGG
GAAGTGGAAAATGATATGCGCATTCAGGAAGCGTTCAGCCGCATCGTACCCGCTGCGGAGTTTATCGCCCGGCGCGACGC
GCAGAAGAAAGCTGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References