Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4634495..4635097 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDU34_RS22230 Protein ID WP_000897305.1
Coordinates 4634786..4635097 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDU34_RS22225 Protein ID WP_000356397.1
Coordinates 4634495..4634785 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS22200 (4630420) 4630420..4631322 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDU34_RS22205 (4631319) 4631319..4631954 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDU34_RS22210 (4631951) 4631951..4632880 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDU34_RS22215 (4633210) 4633210..4633452 - 243 WP_001087409.1 protein YiiF -
QDU34_RS22220 (4633672) 4633672..4633890 - 219 WP_001315930.1 CopG family transcriptional regulator -
QDU34_RS22225 (4634495) 4634495..4634785 - 291 WP_000356397.1 NadS family protein Antitoxin
QDU34_RS22230 (4634786) 4634786..4635097 - 312 WP_000897305.1 hypothetical protein Toxin
QDU34_RS22235 (4635326) 4635326..4636234 + 909 WP_001162704.1 alpha/beta hydrolase -
QDU34_RS22240 (4636298) 4636298..4637239 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDU34_RS22245 (4637284) 4637284..4637721 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QDU34_RS22250 (4637718) 4637718..4638590 - 873 WP_000920762.1 virulence factor BrkB family protein -
QDU34_RS22255 (4638584) 4638584..4639183 - 600 WP_001295269.1 glucose-1-phosphatase -
QDU34_RS22260 (4639282) 4639282..4640067 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278583 WP_000897305.1 NZ_CP123046:c4635097-4634786 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278583 WP_000356397.1 NZ_CP123046:c4634785-4634495 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References