Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3780760..3781301 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QDU34_RS18335 Protein ID WP_000615976.1
Coordinates 3781023..3781301 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QDU34_RS18330 Protein ID WP_000729704.1
Coordinates 3780760..3781020 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS18305 (3775796) 3775796..3776935 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
QDU34_RS18310 (3776919) 3776919..3779012 + 2094 WP_001597626.1 flagellar biosynthesis protein FlhA -
QDU34_RS18315 (3779117) 3779117..3779395 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QDU34_RS18320 (3779388) 3779388..3779744 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
QDU34_RS18325 (3779801) 3779801..3780574 - 774 WP_000543897.1 C40 family peptidase -
QDU34_RS18330 (3780760) 3780760..3781020 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDU34_RS18335 (3781023) 3781023..3781301 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDU34_RS18340 (3781457) 3781457..3782197 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDU34_RS18345 (3782168) 3782168..3782935 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDU34_RS18350 (3783141) 3783141..3783719 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T278579 WP_000615976.1 NZ_CP123046:3781023-3781301 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT278579 WP_000729704.1 NZ_CP123046:3780760-3781020 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References