Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1825056..1825558 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QDU34_RS08735 Protein ID WP_000767829.1
Coordinates 1825304..1825558 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag QDU34_RS08730 Protein ID WP_001610372.1
Coordinates 1825056..1825307 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS08705 (1820234) 1820234..1821301 - 1068 WP_000080141.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDU34_RS08710 (1821301) 1821301..1822371 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
QDU34_RS08715 (1822368) 1822368..1823672 - 1305 WP_001367667.1 histidinol dehydrogenase -
QDU34_RS08720 (1823678) 1823678..1824577 - 900 WP_000131792.1 ATP phosphoribosyltransferase -
QDU34_RS08725 (1824723) 1824723..1824773 - 51 WP_001364200.1 his operon leader peptide -
QDU34_RS08730 (1825056) 1825056..1825307 + 252 WP_001610372.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDU34_RS08735 (1825304) 1825304..1825558 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDU34_RS08740 (1825641) 1825641..1826465 + 825 WP_000754737.1 SDR family oxidoreductase -
QDU34_RS08745 (1826511) 1826511..1827440 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QDU34_RS08750 (1827655) 1827655..1827717 + 63 WP_010723108.1 membrane protein YoeI -
QDU34_RS08755 (1827707) 1827707..1829065 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDU34_RS08760 (1829245) 1829245..1830303 + 1059 WP_000492330.1 thiosulfate utilization transporter TsuA/YeeE -
QDU34_RS08765 (1830317) 1830317..1830544 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T278571 WP_000767829.1 NZ_CP123046:1825304-1825558 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9289.55 Da        Isoelectric Point: 4.7954

>AT278571 WP_001610372.1 NZ_CP123046:1825056-1825307 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLIDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References