Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 599169..599968 Replicon chromosome
Accession NZ_CP123046
Organism Escherichia coli strain EC0430

Toxin (Protein)


Gene name yhaV Uniprot ID A0A6H2GMC5
Locus tag QDU34_RS02935 Protein ID WP_000347279.1
Coordinates 599169..599633 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDU34_RS02940 Protein ID WP_001307405.1
Coordinates 599633..599968 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDU34_RS02905 (594170) 594170..594604 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDU34_RS02910 (594622) 594622..595500 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
QDU34_RS02915 (595490) 595490..596269 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDU34_RS02920 (596280) 596280..596753 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDU34_RS02925 (596776) 596776..598056 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDU34_RS02930 (598305) 598305..599114 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDU34_RS02935 (599169) 599169..599633 - 465 WP_000347279.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDU34_RS02940 (599633) 599633..599968 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDU34_RS02945 (600117) 600117..601688 - 1572 WP_001273741.1 galactarate dehydratase -
QDU34_RS02950 (602063) 602063..603397 + 1335 WP_128995326.1 galactarate/glucarate/glycerate transporter GarP -
QDU34_RS02955 (603413) 603413..604183 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17869.24 Da        Isoelectric Point: 9.4947

>T278567 WP_000347279.1 NZ_CP123046:c599633-599169 [Escherichia coli]
MDFPQRVNGWVLYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESFTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278567 WP_001307405.1 NZ_CP123046:c599968-599633 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6H2GMC5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References