Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 363764..364410 Replicon chromosome
Accession NZ_CP123043
Organism Klebsiella pneumoniae strain KP161637

Toxin (Protein)


Gene name higB Uniprot ID A0A486RBU5
Locus tag QDF61_RS01690 Protein ID WP_032410616.1
Coordinates 363764..364111 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag QDF61_RS01695 Protein ID WP_002920557.1
Coordinates 364111..364410 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDF61_RS01680 (359690) 359690..361123 + 1434 WP_002920564.1 glycogen synthase GlgA -
QDF61_RS01685 (361141) 361141..363588 + 2448 WP_002920561.1 glycogen phosphorylase -
QDF61_RS01690 (363764) 363764..364111 + 348 WP_032410616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDF61_RS01695 (364111) 364111..364410 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
QDF61_RS01700 (364473) 364473..365981 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
QDF61_RS01705 (366186) 366186..366515 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
QDF61_RS01710 (366566) 366566..367396 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
QDF61_RS01715 (367446) 367446..368204 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13545.55 Da        Isoelectric Point: 5.6802

>T278552 WP_032410616.1 NZ_CP123043:363764-364111 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT278552 WP_002920557.1 NZ_CP123043:364111-364410 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RBU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References