Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1426088..1426735 Replicon chromosome
Accession NC_017933
Organism Cronobacter sakazakii ES15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ES15_RS06785 Protein ID WP_014728495.1
Coordinates 1426088..1426435 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ES15_RS06790 Protein ID WP_007869363.1
Coordinates 1426436..1426735 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ES15_RS06760 1421372..1422382 + 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -
ES15_RS06765 1422890..1423603 - 714 WP_007794951.1 outer membrane permeability protein SanA -
ES15_RS06770 1423728..1424612 - 885 WP_014728494.1 cytidine deaminase -
ES15_RS06775 1424742..1425437 - 696 WP_007869369.1 CidB/LrgB family autolysis modulator -
ES15_RS06780 1425434..1425835 - 402 WP_007869367.1 CidA/LrgA family protein -
ES15_RS06785 1426088..1426435 + 348 WP_014728495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ES15_RS06790 1426436..1426735 + 300 WP_007869363.1 XRE family transcriptional regulator Antitoxin
ES15_RS06795 1426806..1427738 + 933 WP_014728496.1 tRNA dihydrouridine(16) synthase DusC -
ES15_RS06800 1427741..1428664 - 924 WP_014728497.1 LysR family transcriptional regulator -
ES15_RS06805 1428737..1429696 + 960 WP_014728498.1 MBL fold metallo-hydrolase -
ES15_RS20055 1429733..1429816 - 84 WP_000691708.1 protein YohP -
ES15_RS06810 1429989..1430762 + 774 WP_007899548.1 SDR family oxidoreductase -
ES15_RS06815 1430759..1431325 - 567 WP_014728499.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13429.71 Da        Isoelectric Point: 10.3525

>T27849 WP_014728495.1 NC_017933:1426088-1426435 [Cronobacter sakazakii ES15]
MWTIYLTHEFECWLARQPQPLQEDVLAALGLLKIKGPHLGRPYADTLKGSRHTGMKALRVQHAGRPIRAFYAFDPHRYAI
VLCAAQKKGDEKRFYRVMLRVADKLFSHYLNHREV

Download         Length: 348 bp

>T27849 NC_017933:1426088-1426435 [Cronobacter sakazakii ES15]
ATGTGGACTATTTACCTTACTCACGAGTTTGAGTGCTGGCTCGCGAGACAGCCGCAGCCGTTGCAGGAAGATGTGCTGGC
CGCGCTGGGGCTTTTGAAAATCAAAGGTCCGCACCTCGGGCGTCCGTATGCCGATACGCTCAAAGGCTCGCGTCACACGG
GTATGAAGGCATTACGGGTTCAGCACGCCGGGCGGCCCATACGCGCCTTTTACGCTTTTGATCCGCACCGTTATGCGATT
GTGCTGTGCGCGGCACAGAAAAAGGGGGATGAAAAGCGGTTTTACCGGGTCATGCTGCGCGTCGCTGACAAACTGTTTAG
CCACTATCTGAACCACCGGGAGGTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11093.70 Da        Isoelectric Point: 4.8840

>AT27849 WP_007869363.1 NC_017933:1426436-1426735 [Cronobacter sakazakii ES15]
MKTFDEVLAAQTPEARERIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp

>AT27849 NC_017933:1426436-1426735 [Cronobacter sakazakii ES15]
ATGAAGACGTTTGATGAAGTGCTGGCGGCGCAGACCCCGGAGGCCCGCGAACGCATCGAAGAGAAAACGGCGCAGCTGCT
GCTGGAAACCCATCTGTATGCGCTGCGCGAGGCGCTCAGCGTGTCGCAAACCGAGATGGCGCGCCAGATGGGTATCGCCC
AGCCGTCGGTCGCGGCTATCGAACAGCGCGGCAACGAGATGAAAATCTCAACGCTTAAGCGCTATGTCGAAGCCCTGGGC
GGCACGGTGCGGCTGGATGTCGAGCTGCCGGACGGCCAGCGTTTCGGTTTTACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References