Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 629558..630357 Replicon chromosome
Accession NZ_CP123029
Organism Escherichia coli strain 20-20

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QEN57_RS03055 Protein ID WP_000347251.1
Coordinates 629558..630022 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QEN57_RS03060 Protein ID WP_001307405.1
Coordinates 630022..630357 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN57_RS03025 (624559) 624559..624993 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QEN57_RS03030 (625011) 625011..625889 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QEN57_RS03035 (625879) 625879..626658 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QEN57_RS03040 (626669) 626669..627142 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QEN57_RS03045 (627165) 627165..628445 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
QEN57_RS03050 (628694) 628694..629503 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QEN57_RS03055 (629558) 629558..630022 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QEN57_RS03060 (630022) 630022..630357 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QEN57_RS03065 (630506) 630506..632077 - 1572 WP_001273761.1 galactarate dehydratase -
QEN57_RS03070 (632452) 632452..633786 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
QEN57_RS03075 (633802) 633802..634572 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T278487 WP_000347251.1 NZ_CP123029:c630022-629558 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278487 WP_001307405.1 NZ_CP123029:c630357-630022 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References