Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 658759..659558 Replicon chromosome
Accession NZ_CP123017
Organism Escherichia coli strain 19-7

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QEN55_RS03235 Protein ID WP_000347251.1
Coordinates 658759..659223 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QEN55_RS03240 Protein ID WP_001307405.1
Coordinates 659223..659558 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN55_RS03205 (653760) 653760..654194 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QEN55_RS03210 (654212) 654212..655090 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QEN55_RS03215 (655080) 655080..655859 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QEN55_RS03220 (655870) 655870..656343 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QEN55_RS03225 (656366) 656366..657646 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
QEN55_RS03230 (657895) 657895..658704 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QEN55_RS03235 (658759) 658759..659223 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QEN55_RS03240 (659223) 659223..659558 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QEN55_RS03245 (659707) 659707..661278 - 1572 WP_001273761.1 galactarate dehydratase -
QEN55_RS03250 (661653) 661653..662987 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
QEN55_RS03255 (663003) 663003..663773 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T278436 WP_000347251.1 NZ_CP123017:c659223-658759 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278436 WP_001307405.1 NZ_CP123017:c659558-659223 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References