Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 656171..656970 Replicon chromosome
Accession NZ_CP123013
Organism Escherichia coli strain 18-4

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag QEN56_RS03210 Protein ID WP_000347251.1
Coordinates 656171..656635 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QEN56_RS03215 Protein ID WP_001307405.1
Coordinates 656635..656970 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN56_RS03180 (651172) 651172..651606 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QEN56_RS03185 (651624) 651624..652502 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QEN56_RS03190 (652492) 652492..653271 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QEN56_RS03195 (653282) 653282..653755 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QEN56_RS03200 (653778) 653778..655058 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
QEN56_RS03205 (655307) 655307..656116 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QEN56_RS03210 (656171) 656171..656635 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QEN56_RS03215 (656635) 656635..656970 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QEN56_RS03220 (657119) 657119..658690 - 1572 WP_001273761.1 galactarate dehydratase -
QEN56_RS03225 (659065) 659065..660399 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
QEN56_RS03230 (660415) 660415..661185 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T278410 WP_000347251.1 NZ_CP123013:c656635-656171 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278410 WP_001307405.1 NZ_CP123013:c656970-656635 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References