Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4653922..4654463 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QEN28_RS22565 Protein ID WP_000615976.1
Coordinates 4654185..4654463 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QEN28_RS22560 Protein ID WP_000729704.1
Coordinates 4653922..4654182 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS22535 (4649705) 4649705..4650490 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
QEN28_RS22540 (4650462) 4650462..4652174 + 1713 Protein_4438 flagellar biosynthesis protein FlhA -
QEN28_RS22545 (4652279) 4652279..4652557 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QEN28_RS22550 (4652550) 4652550..4652906 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
QEN28_RS22555 (4652963) 4652963..4653736 - 774 WP_000543895.1 C40 family peptidase -
QEN28_RS22560 (4653922) 4653922..4654182 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QEN28_RS22565 (4654185) 4654185..4654463 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QEN28_RS22570 (4654619) 4654619..4655359 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QEN28_RS22575 (4655330) 4655330..4656097 - 768 WP_000333380.1 class II glutamine amidotransferase -
QEN28_RS22580 (4656303) 4656303..4656881 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T278406 WP_000615976.1 NZ_CP123009:4654185-4654463 [Escherichia coli O155]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT278406 WP_000729704.1 NZ_CP123009:4653922-4654182 [Escherichia coli O155]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References