Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4542463..4543262 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag QEN28_RS21885 Protein ID WP_000347266.1
Coordinates 4542463..4542927 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QEN28_RS21890 Protein ID WP_001307405.1
Coordinates 4542927..4543262 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS21855 (4537464) 4537464..4537898 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QEN28_RS21860 (4537916) 4537916..4538794 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
QEN28_RS21865 (4538784) 4538784..4539563 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QEN28_RS21870 (4539574) 4539574..4540047 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QEN28_RS21875 (4540070) 4540070..4541350 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
QEN28_RS21880 (4541599) 4541599..4542408 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QEN28_RS21885 (4542463) 4542463..4542927 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QEN28_RS21890 (4542927) 4542927..4543262 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QEN28_RS21895 (4543411) 4543411..4544982 - 1572 WP_001273741.1 galactarate dehydratase -
QEN28_RS21900 (4545357) 4545357..4546691 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QEN28_RS21905 (4546707) 4546707..4547477 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T278405 WP_000347266.1 NZ_CP123009:c4542927-4542463 [Escherichia coli O155]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278405 WP_001307405.1 NZ_CP123009:c4543262-4542927 [Escherichia coli O155]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References