Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3951468..3952070 Replicon chromosome
Accession NZ_CP123009
Organism Escherichia coli O155 strain NWU_3

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QEN28_RS18950 Protein ID WP_000897305.1
Coordinates 3951759..3952070 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QEN28_RS18945 Protein ID WP_000356397.1
Coordinates 3951468..3951758 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN28_RS18920 (3947393) 3947393..3948295 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QEN28_RS18925 (3948292) 3948292..3948927 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QEN28_RS18930 (3948924) 3948924..3949853 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QEN28_RS18935 (3950183) 3950183..3950425 - 243 WP_001087409.1 protein YiiF -
QEN28_RS18940 (3950645) 3950645..3950863 - 219 WP_001315930.1 CopG family transcriptional regulator -
QEN28_RS18945 (3951468) 3951468..3951758 - 291 WP_000356397.1 NadS family protein Antitoxin
QEN28_RS18950 (3951759) 3951759..3952070 - 312 WP_000897305.1 hypothetical protein Toxin
QEN28_RS18955 (3952299) 3952299..3953207 + 909 WP_001162704.1 alpha/beta hydrolase -
QEN28_RS18960 (3953271) 3953271..3954212 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QEN28_RS18965 (3954257) 3954257..3954694 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QEN28_RS18970 (3954691) 3954691..3955563 - 873 WP_000920762.1 virulence factor BrkB family protein -
QEN28_RS18975 (3955557) 3955557..3956156 - 600 WP_001295269.1 glucose-1-phosphatase -
QEN28_RS18980 (3956255) 3956255..3957040 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278400 WP_000897305.1 NZ_CP123009:c3952070-3951759 [Escherichia coli O155]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278400 WP_000356397.1 NZ_CP123009:c3951758-3951468 [Escherichia coli O155]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References