Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4658278..4658819 Replicon chromosome
Accession NZ_CP123008
Organism Escherichia coli strain NWU_4

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QEN27_RS22600 Protein ID WP_000615976.1
Coordinates 4658541..4658819 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QEN27_RS22595 Protein ID WP_000729704.1
Coordinates 4658278..4658538 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN27_RS22570 (4654061) 4654061..4654846 - 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -
QEN27_RS22575 (4654818) 4654818..4656530 + 1713 Protein_4445 flagellar biosynthesis protein FlhA -
QEN27_RS22580 (4656635) 4656635..4656913 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QEN27_RS22585 (4656906) 4656906..4657262 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
QEN27_RS22590 (4657319) 4657319..4658092 - 774 WP_000543895.1 C40 family peptidase -
QEN27_RS22595 (4658278) 4658278..4658538 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QEN27_RS22600 (4658541) 4658541..4658819 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QEN27_RS22605 (4658975) 4658975..4659715 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QEN27_RS22610 (4659686) 4659686..4660453 - 768 WP_000333380.1 class II glutamine amidotransferase -
QEN27_RS22615 (4660659) 4660659..4661237 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T278381 WP_000615976.1 NZ_CP123008:4658541-4658819 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT278381 WP_000729704.1 NZ_CP123008:4658278-4658538 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References