Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3910764..3911366 Replicon chromosome
Accession NZ_CP123008
Organism Escherichia coli strain NWU_4

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QEN27_RS18845 Protein ID WP_000897305.1
Coordinates 3910764..3911075 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QEN27_RS18850 Protein ID WP_000356397.1
Coordinates 3911076..3911366 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN27_RS18815 (3905794) 3905794..3906579 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
QEN27_RS18820 (3906678) 3906678..3907277 + 600 WP_001295269.1 glucose-1-phosphatase -
QEN27_RS18825 (3907271) 3907271..3908143 + 873 WP_000920762.1 virulence factor BrkB family protein -
QEN27_RS18830 (3908140) 3908140..3908577 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QEN27_RS18835 (3908622) 3908622..3909563 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QEN27_RS18840 (3909627) 3909627..3910535 - 909 WP_001162704.1 alpha/beta hydrolase -
QEN27_RS18845 (3910764) 3910764..3911075 + 312 WP_000897305.1 hypothetical protein Toxin
QEN27_RS18850 (3911076) 3911076..3911366 + 291 WP_000356397.1 NadS family protein Antitoxin
QEN27_RS18855 (3911971) 3911971..3912189 + 219 WP_001315930.1 CopG family transcriptional regulator -
QEN27_RS18860 (3912409) 3912409..3912651 + 243 WP_001087409.1 protein YiiF -
QEN27_RS18865 (3912981) 3912981..3913910 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QEN27_RS18870 (3913907) 3913907..3914542 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QEN27_RS18875 (3914539) 3914539..3915441 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278378 WP_000897305.1 NZ_CP123008:3910764-3911075 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278378 WP_000356397.1 NZ_CP123008:3911076-3911366 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References