Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4868011..4868516 Replicon chromosome
Accession NC_017911
Organism Pseudomonas fluorescens A506

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0W0MVT7
Locus tag PFLA506_RS21815 Protein ID WP_014719853.1
Coordinates 4868262..4868516 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID I4K3F7
Locus tag PFLA506_RS21810 Protein ID WP_003194039.1
Coordinates 4868011..4868265 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFLA506_RS21795 4863449..4865350 + 1902 WP_014719850.1 alkaline phosphatase family protein -
PFLA506_RS21800 4865489..4866502 + 1014 WP_014719851.1 sensor domain-containing diguanylate cyclase -
PFLA506_RS21805 4866613..4867866 + 1254 WP_014719852.1 aspartate aminotransferase family protein -
PFLA506_RS21810 4868011..4868265 + 255 WP_003194039.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PFLA506_RS21815 4868262..4868516 + 255 WP_014719853.1 Txe/YoeB family addiction module toxin Toxin
PFLA506_RS21820 4868615..4869331 + 717 WP_014719854.1 hypothetical protein -
PFLA506_RS21825 4869342..4870463 - 1122 WP_014719855.1 aminotransferase class V-fold PLP-dependent enzyme -
PFLA506_RS21830 4870465..4871667 - 1203 WP_019817486.1 MFS transporter -
PFLA506_RS21835 4871667..4872917 - 1251 WP_014719857.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9977.51 Da        Isoelectric Point: 8.0456

>T27836 WP_014719853.1 NC_017911:4868262-4868516 [Pseudomonas fluorescens A506]
MKILFTPEGWDDYLWFQQNDKAGLKRINLLIKAIQRDPFGGVGKPEPLKHNLSGFWSRRITAEHRLVYGIEDDEVQILMC
RYHY

Download         Length: 255 bp

>T27836 NC_017911:4868262-4868516 [Pseudomonas fluorescens A506]
ATGAAAATACTCTTTACCCCTGAAGGCTGGGACGACTACCTCTGGTTTCAACAGAACGACAAAGCCGGGCTCAAGCGCAT
CAATCTCTTGATCAAGGCCATACAAAGAGACCCGTTCGGCGGCGTGGGGAAGCCTGAACCCCTCAAACATAACCTGAGTG
GTTTCTGGTCTCGACGAATCACCGCGGAGCATCGTTTGGTTTATGGCATCGAGGATGATGAAGTACAAATATTGATGTGC
CGCTACCACTACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9576.93 Da        Isoelectric Point: 7.2034

>AT27836 WP_003194039.1 NC_017911:4868011-4868265 [Pseudomonas fluorescens A506]
METINYTNARAHLSETMDRVNDDHVPLLLTRQKGEPVVMISLSEFNALEETAYLLRSPKNAERLINSVNSLRAGKAKPRR
LIEE

Download         Length: 255 bp

>AT27836 NC_017911:4868011-4868265 [Pseudomonas fluorescens A506]
ATGGAAACTATCAACTACACCAACGCCCGAGCCCATCTGTCCGAAACGATGGACCGCGTCAATGATGATCACGTCCCACT
TCTACTGACTCGACAAAAAGGCGAGCCCGTGGTGATGATCTCGTTATCAGAGTTCAATGCTCTGGAAGAGACGGCTTACC
TGCTGCGCTCGCCTAAAAATGCCGAACGTCTCATTAACTCAGTCAACAGCTTACGAGCAGGCAAAGCCAAGCCAAGGCGG
TTGATTGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0MVT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0MVN5

References