278333

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1187955..1188573 Replicon chromosome
Accession NZ_CP123003
Organism Sinorhizobium meliloti strain BIM B-442D

Toxin (Protein)


Gene name higB Uniprot ID Q92R61
Locus tag QC756_RS05815 Protein ID WP_010969011.1
Coordinates 1188277..1188573 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QC756_RS05810 Protein ID WP_010969010.1
Coordinates 1187955..1188263 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC756_RS05765 (QC756_05765) 1183610..1183852 + 243 WP_280097526.1 hypothetical protein -
QC756_RS05770 (QC756_05770) 1183907..1184272 + 366 WP_280097527.1 hypothetical protein -
QC756_RS05775 (QC756_05775) 1184726..1184926 + 201 WP_127524705.1 hypothetical protein -
QC756_RS05780 (QC756_05780) 1185121..1185270 + 150 WP_014529577.1 hypothetical protein -
QC756_RS05785 (QC756_05785) 1185493..1186629 - 1137 Protein_1137 TlpA disulfide reductase family protein -
QC756_RS05790 (QC756_05790) 1186791..1186872 - 82 Protein_1138 nitrogen fixation protein FixA -
QC756_RS05795 (QC756_05795) 1186876..1187375 + 500 Protein_1139 ATP-dependent DNA ligase -
QC756_RS05805 (QC756_05805) 1187714..1187944 - 231 WP_026029805.1 hypothetical protein -
QC756_RS05810 (QC756_05810) 1187955..1188263 - 309 WP_010969010.1 HigA family addiction module antitoxin Antitoxin
QC756_RS05815 (QC756_05815) 1188277..1188573 - 297 WP_010969011.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QC756_RS05820 (QC756_05820) 1188621..1188926 - 306 WP_003527305.1 hypothetical protein -
QC756_RS05825 (QC756_05825) 1189254..1190291 + 1038 WP_003527304.1 porin -
QC756_RS05830 (QC756_05830) 1190401..1191468 - 1068 WP_014526650.1 site-specific integrase -
QC756_RS05835 (QC756_05835) 1191509..1192558 - 1050 WP_010969013.1 porin -
QC756_RS05840 (QC756_05840) 1192772..1193260 - 489 WP_013844230.1 BA14K family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11677.11 Da        Isoelectric Point: 6.7260

>T278333 WP_010969011.1 NZ_CP123003:c1188573-1188277 [Sinorhizobium meliloti]
VIVGFRDDWLRTFFVDDVRSRNIPYDLEARLFRKLQMIDDAATDQDLRVPPSNHFEKLRGNLAGLHSIRVNQQWRLIFRW
DGTRGEADGIYLDDHSYR

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11588.44 Da        Isoelectric Point: 11.0603

>AT278333 WP_010969010.1 NZ_CP123003:c1188263-1187955 [Sinorhizobium meliloti]
MLTTKRKPATVGEILTEEFMRPMGLTQGALAEAMGVQRKHVNELCGNRRNVTAATALILARVFGNSPDFWLNVQRRNDLW
LVMNTPKERERIERARPLENAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92R61

Antitoxin

Source ID Structure

References