Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2540778..2541389 Replicon chromosome
Accession NZ_CP123000
Organism Neorhizobium petrolearium strain OS53

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QEO92_RS12785 Protein ID WP_227703283.1
Coordinates 2541108..2541389 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QEO92_RS12780 Protein ID WP_037148097.1
Coordinates 2540778..2541080 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEO92_RS12750 (QEO92_12750) 2536599..2537186 - 588 WP_227703278.1 ATP-dependent Clp protease proteolytic subunit -
QEO92_RS12755 (QEO92_12755) 2537406..2537993 + 588 WP_227703279.1 HupE/UreJ family protein -
QEO92_RS12760 (QEO92_12760) 2538090..2538905 + 816 WP_227703280.1 DUF2076 domain-containing protein -
QEO92_RS12765 (QEO92_12765) 2538996..2539193 - 198 WP_227703281.1 hypothetical protein -
QEO92_RS12770 (QEO92_12770) 2539215..2539679 - 465 WP_210054088.1 preQ(1) synthase -
QEO92_RS12775 (QEO92_12775) 2539676..2540596 - 921 WP_227703282.1 cation diffusion facilitator family transporter -
QEO92_RS12780 (QEO92_12780) 2540778..2541080 - 303 WP_037148097.1 HigA family addiction module antitoxin Antitoxin
QEO92_RS12785 (QEO92_12785) 2541108..2541389 - 282 WP_227703283.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QEO92_RS12790 (QEO92_12790) 2541471..2542079 - 609 WP_227703284.1 LysE family translocator -
QEO92_RS12795 (QEO92_12795) 2542136..2542639 - 504 WP_227703285.1 GNAT family protein -
QEO92_RS12800 (QEO92_12800) 2542642..2544831 - 2190 WP_037148103.1 anthranilate synthase -
QEO92_RS12805 (QEO92_12805) 2545109..2546008 + 900 WP_227703286.1 extensin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-95)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10590.93 Da        Isoelectric Point: 8.0477

>T278320 WP_227703283.1 NZ_CP123000:c2541389-2541108 [Neorhizobium petrolearium]
VIRSFRDKLTQSIDDGTVRKGFPSDLVRRAQQLLTVLNAATSLEDLRSPPGNRLEKLSGDREGQHSIRINKQWRICFVWT
EAGPGEVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11487.45 Da        Isoelectric Point: 9.5724

>AT278320 WP_037148097.1 NZ_CP123000:c2541080-2540778 [Neorhizobium petrolearium]
MSVSKLPPIHPGEILCDLYLRPLEMTPYALAKKLNVPRTRIERIVAQKTGITSDTALRLARFFRTSPEFWMNLQNSFDLK
IEAQALKDELKRIPEYEAAA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References