Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 702467..703043 Replicon chromosome
Accession NZ_CP122961
Organism Halomonas alkaliantarctica strain MSP3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QEN58_RS03210 Protein ID WP_280105721.1
Coordinates 702467..702745 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag QEN58_RS03215 Protein ID WP_022520034.1
Coordinates 702756..703043 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QEN58_RS03180 (QEN58_03180) 697699..697974 + 276 WP_280105716.1 hypothetical protein -
QEN58_RS03185 (QEN58_03185) 698056..698553 + 498 WP_280105717.1 GNAT family N-acetyltransferase -
QEN58_RS03190 (QEN58_03190) 698527..699632 - 1106 Protein_615 IS3 family transposase -
QEN58_RS03195 (QEN58_03195) 700236..701264 + 1029 WP_280105718.1 S8 family serine peptidase -
QEN58_RS03200 (QEN58_03200) 701505..701627 + 123 WP_280105719.1 hypothetical protein -
QEN58_RS03205 (QEN58_03205) 701903..702340 + 438 WP_280105720.1 hypothetical protein -
QEN58_RS03210 (QEN58_03210) 702467..702745 + 279 WP_280105721.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QEN58_RS03215 (QEN58_03215) 702756..703043 + 288 WP_022520034.1 HigA family addiction module antitoxin Antitoxin
QEN58_RS03220 (QEN58_03220) 703150..703572 - 423 WP_280105722.1 hypothetical protein -
QEN58_RS03225 (QEN58_03225) 703672..704325 + 654 WP_280105723.1 DsbA family oxidoreductase -
QEN58_RS03230 (QEN58_03230) 704419..705612 - 1194 WP_280105724.1 homoserine O-acetyltransferase -
QEN58_RS03235 (QEN58_03235) 705687..706859 - 1173 WP_280105725.1 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase -
QEN58_RS03240 (QEN58_03240) 706978..707832 + 855 WP_280105726.1 NAD-dependent protein deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10334.73 Da        Isoelectric Point: 10.3742

>T278301 WP_280105721.1 NZ_CP122961:702467-702745 [Halomonas alkaliantarctica]
MIRSFKHKGLAKFFKSGSTAGIQAAHAKRLRLILGRLNAASDTKDMDLPGLRLHELSGNRSGIWSVTVSGNWRVTFRFED
GDAEIVNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10442.08 Da        Isoelectric Point: 7.3596

>AT278301 WP_022520034.1 NZ_CP122961:702756-703043 [Halomonas alkaliantarctica]
MLMHNPPHPGEVLRELCLEPLGLTVTAAAEALGVSRKTLSAVLNGKAGISPEMAVRLSIAFDTSAESWLNQQSQYELWHA
EQHRKELKVKRLVAA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References