278300

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1404223..1404811 Replicon chromosome
Accession NZ_CP122956
Organism Helicobacter pylori strain BT112

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag QAD58_RS06795 Protein ID WP_286448266.1
Coordinates 1404530..1404811 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID T5CU17
Locus tag QAD58_RS06790 Protein ID WP_000065285.1
Coordinates 1404223..1404537 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAD58_RS06770 (QAD58_06775) 1399757..1400413 + 657 WP_286448265.1 ParA family protein -
QAD58_RS06775 (QAD58_06780) 1400495..1400779 + 285 WP_000394639.1 hypothetical protein -
QAD58_RS06780 (QAD58_06785) 1400861..1401994 + 1134 WP_286449048.1 hypothetical protein -
QAD58_RS06785 (QAD58_06790) 1402019..1403928 - 1910 Protein_1318 relaxase/mobilization nuclease domain-containing protein -
QAD58_RS06790 (QAD58_06795) 1404223..1404537 + 315 WP_000065285.1 hypothetical protein Antitoxin
QAD58_RS06795 (QAD58_06800) 1404530..1404811 + 282 WP_286448266.1 YafQ family addiction module toxin Toxin
QAD58_RS06800 (QAD58_06805) 1405086..1405556 - 471 WP_180527932.1 TraM recognition domain-containing protein -
QAD58_RS06805 (QAD58_06810) 1405584..1405844 - 261 WP_000602756.1 hypothetical protein -
QAD58_RS06810 (QAD58_06815) 1405845..1406063 - 219 WP_286448267.1 TrbC/VirB2 family protein -
QAD58_RS06815 (QAD58_06820) 1406137..1408053 - 1917 WP_286448268.1 hypothetical protein -
QAD58_RS06820 (QAD58_06825) 1408064..1408838 - 775 Protein_1325 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10972.86 Da        Isoelectric Point: 10.0752

>T278300 WP_286448266.1 NZ_CP122956:1404530-1404811 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDRLKEQRPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12121.58 Da        Isoelectric Point: 5.2066

>AT278300 WP_000065285.1 NZ_CP122956:1404223-1404537 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T5CU17

References