Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 1000026..1000614 Replicon chromosome
Accession NZ_CP122952
Organism Helicobacter pylori strain BS27-1

Toxin (Protein)


Gene name TfiT Uniprot ID A0A0B2EXV0
Locus tag QAP05_RS04795 Protein ID WP_039091279.1
Coordinates 1000026..1000307 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID I9TJZ8
Locus tag QAP05_RS04800 Protein ID WP_000073112.1
Coordinates 1000300..1000614 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAP05_RS04770 (QAP05_04770) 995051..995344 + 294 WP_286490750.1 hypothetical protein -
QAP05_RS04775 (QAP05_04775) 996746..997186 + 441 WP_286494543.1 mobilization protein -
QAP05_RS04780 (QAP05_04780) 997183..997473 + 291 WP_096468234.1 hypothetical protein -
QAP05_RS04785 (QAP05_04785) 997474..998032 + 559 Protein_925 hypothetical protein -
QAP05_RS04790 (QAP05_04790) 998033..999775 + 1743 WP_286490752.1 type IV secretory system conjugative DNA transfer family protein -
QAP05_RS04795 (QAP05_04795) 1000026..1000307 - 282 WP_039091279.1 YafQ family addiction module toxin Toxin
QAP05_RS04800 (QAP05_04800) 1000300..1000614 - 315 WP_000073112.1 hypothetical protein Antitoxin
QAP05_RS04805 (QAP05_04805) 1001027..1002940 + 1914 WP_286490754.1 relaxase/mobilization nuclease domain-containing protein -
QAP05_RS04810 (QAP05_04810) 1002965..1004143 - 1179 WP_286490756.1 hypothetical protein -
QAP05_RS04815 (QAP05_04815) 1004175..1004459 - 285 WP_000394650.1 hypothetical protein -
QAP05_RS04820 (QAP05_04820) 1004541..1005199 - 659 Protein_932 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10931.91 Da        Isoelectric Point: 10.0264

>T278295 WP_039091279.1 NZ_CP122952:c1000307-1000026 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITENDVTSIVDCLKKQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12092.53 Da        Isoelectric Point: 5.2066

>AT278295 WP_000073112.1 NZ_CP122952:c1000614-1000300 [Helicobacter pylori]
MSNVITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
CDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B2EXV0

Antitoxin

Source ID Structure
AlphaFold DB I9TJZ8

References