Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 138802..139390 Replicon chromosome
Accession NZ_CP122950
Organism Helicobacter pylori strain BS28-1

Toxin (Protein)


Gene name TfiT Uniprot ID K2LF18
Locus tag QAP01_RS00650 Protein ID WP_000921926.1
Coordinates 138802..139083 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID K2KPE8
Locus tag QAP01_RS00655 Protein ID WP_000065300.1
Coordinates 139076..139390 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QAP01_RS00640 (136371) 136371..136799 + 429 Protein_123 hypothetical protein -
QAP01_RS00645 (136800) 136800..138527 + 1728 WP_286498352.1 type IV secretory system conjugative DNA transfer family protein -
QAP01_RS00650 (138802) 138802..139083 - 282 WP_000921926.1 YafQ family addiction module toxin Toxin
QAP01_RS00655 (139076) 139076..139390 - 315 WP_000065300.1 hypothetical protein Antitoxin
QAP01_RS00660 (139726) 139726..141636 + 1911 WP_286498355.1 relaxase/mobilization nuclease domain-containing protein -
QAP01_RS00665 (141660) 141660..142823 - 1164 WP_286498357.1 hypothetical protein -
QAP01_RS00670 (142855) 142855..143139 - 285 WP_286498359.1 hypothetical protein -
QAP01_RS00675 (143221) 143221..143394 - 174 Protein_130 ParA family protein -
QAP01_RS00680 (143391) 143391..144062 + 672 Protein_131 conjugal transfer protein TrbL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - fliI / fliQ / rfaJ 105309..149664 44355


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10932.89 Da        Isoelectric Point: 9.8257

>T278291 WP_000921926.1 NZ_CP122950:c139083-138802 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRIKESDVTSIVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12194.65 Da        Isoelectric Point: 5.6761

>AT278291 WP_000065300.1 NZ_CP122950:c139390-139076 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEGDKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTPSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2LF18

Antitoxin

Source ID Structure
AlphaFold DB K2KPE8

References