Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4878587..4879189 Replicon chromosome
Accession NZ_CP122938
Organism Escherichia coli strain ETEC1701

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDX07_RS24015 Protein ID WP_000897305.1
Coordinates 4878878..4879189 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX07_RS24010 Protein ID WP_000356395.1
Coordinates 4878587..4878877 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX07_RS23975 (4874211) 4874211..4875113 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDX07_RS23980 (4875110) 4875110..4875745 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDX07_RS23985 (4875742) 4875742..4876671 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDX07_RS23990 (4876853) 4876853..4877095 - 243 WP_001306649.1 protein YiiF -
QDX07_RS23995 (4877314) 4877314..4877532 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDX07_RS24000 (4877951) 4877951..4878229 - 279 WP_001306650.1 hypothetical protein -
QDX07_RS24005 (4878281) 4878281..4878502 - 222 WP_001550354.1 hypothetical protein -
QDX07_RS24010 (4878587) 4878587..4878877 - 291 WP_000356395.1 NadS family protein Antitoxin
QDX07_RS24015 (4878878) 4878878..4879189 - 312 WP_000897305.1 hypothetical protein Toxin
QDX07_RS24020 (4879418) 4879418..4880326 + 909 WP_001306651.1 alpha/beta hydrolase -
QDX07_RS24025 (4880495) 4880495..4881409 - 915 WP_225102955.1 transposase -
QDX07_RS24030 (4881422) 4881422..4882309 - 888 Protein_4698 hypothetical protein -
QDX07_RS24035 (4882725) 4882725..4883666 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDX07_RS24040 (4883711) 4883711..4884148 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278281 WP_000897305.1 NZ_CP122938:c4879189-4878878 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT278281 WP_000356395.1 NZ_CP122938:c4878877-4878587 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References