Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1106386..1107113 Replicon chromosome
Accession NZ_CP122938
Organism Escherichia coli strain ETEC1701

Toxin (Protein)


Gene name higB Uniprot ID V0YLE2
Locus tag QDX07_RS05290 Protein ID WP_000547555.1
Coordinates 1106386..1106697 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX07_RS05295 Protein ID WP_000126294.1
Coordinates 1106694..1107113 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX07_RS05265 (1102321) 1102321..1104030 + 1710 WP_063086195.1 formate hydrogenlyase subunit HycE -
QDX07_RS05270 (1104040) 1104040..1104582 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
QDX07_RS05275 (1104582) 1104582..1105349 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
QDX07_RS05280 (1105346) 1105346..1105756 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
QDX07_RS05285 (1105749) 1105749..1106219 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
QDX07_RS05290 (1106386) 1106386..1106697 + 312 WP_000547555.1 type II toxin-antitoxin system HigB family toxin Toxin
QDX07_RS05295 (1106694) 1106694..1107113 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
QDX07_RS05300 (1107192) 1107192..1108616 - 1425 WP_063086210.1 6-phospho-beta-glucosidase AscB -
QDX07_RS05305 (1108625) 1108625..1110082 - 1458 WP_001107888.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
QDX07_RS05310 (1110342) 1110342..1111352 + 1011 WP_029130985.1 DNA-binding transcriptional regulator AscG -
QDX07_RS05315 (1111501) 1111501..1112028 + 528 WP_001078777.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12439.18 Da        Isoelectric Point: 9.5146

>T278261 WP_000547555.1 NZ_CP122938:1106386-1106697 [Escherichia coli]
MHIISKAPFEECARKYPNDALALHSLYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT278261 WP_000126294.1 NZ_CP122938:1106694-1107113 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YLE2

Antitoxin

Source ID Structure

References