Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 611003..611802 Replicon chromosome
Accession NZ_CP122938
Organism Escherichia coli strain ETEC1701

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3A6SBL4
Locus tag QDX07_RS02955 Protein ID WP_062875446.1
Coordinates 611003..611467 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX07_RS02960 Protein ID WP_001307405.1
Coordinates 611467..611802 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX07_RS02925 (606004) 606004..606438 - 435 WP_063086247.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX07_RS02930 (606456) 606456..607334 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX07_RS02935 (607324) 607324..608103 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX07_RS02940 (608114) 608114..608587 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX07_RS02945 (608610) 608610..609890 - 1281 WP_063086249.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX07_RS02950 (610139) 610139..610948 + 810 WP_000072171.1 aga operon transcriptional regulator AgaR -
QDX07_RS02955 (611003) 611003..611467 - 465 WP_062875446.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX07_RS02960 (611467) 611467..611802 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX07_RS02965 (611951) 611951..613522 - 1572 WP_001273756.1 galactarate dehydratase -
QDX07_RS02970 (613897) 613897..615231 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
QDX07_RS02975 (615247) 615247..616022 + 776 Protein_581 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 611003..622294 11291


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17844.22 Da        Isoelectric Point: 9.4942

>T278259 WP_062875446.1 NZ_CP122938:c611467-611003 [Escherichia coli]
MDFPQRVNSWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETD

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278259 WP_001307405.1 NZ_CP122938:c611802-611467 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SBL4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References