Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3713831..3714372 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QDX05_RS18465 Protein ID WP_000615983.1
Coordinates 3714094..3714372 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QDX05_RS18460 Protein ID WP_000729703.1
Coordinates 3713831..3714091 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS18440 (3709506) 3709506..3710291 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QDX05_RS18445 (3710263) 3710263..3711975 + 1713 Protein_3609 flagellar biosynthesis protein FlhA -
QDX05_RS18450 (3712199) 3712199..3712696 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QDX05_RS18455 (3712872) 3712872..3713621 - 750 WP_000056849.1 C40 family peptidase -
QDX05_RS18460 (3713831) 3713831..3714091 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDX05_RS18465 (3714094) 3714094..3714372 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDX05_RS18470 (3714528) 3714528..3715268 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDX05_RS18475 (3715239) 3715239..3716006 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDX05_RS18480 (3716212) 3716212..3716790 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T278249 WP_000615983.1 NZ_CP122929:3714094-3714372 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT278249 WP_000729703.1 NZ_CP122929:3713831-3714091 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References