Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3707634..3708328 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name yafO Uniprot ID Q47157
Locus tag QDX05_RS18425 Protein ID WP_001263489.1
Coordinates 3707634..3708032 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag QDX05_RS18430 Protein ID WP_000554758.1
Coordinates 3708035..3708328 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3703223) 3703223..3703303 - 81 NuclAT_12 - -
- (3703223) 3703223..3703303 - 81 NuclAT_12 - -
- (3703223) 3703223..3703303 - 81 NuclAT_12 - -
- (3703223) 3703223..3703303 - 81 NuclAT_12 - -
QDX05_RS18400 (3703899) 3703899..3704357 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QDX05_RS18405 (3704618) 3704618..3706075 + 1458 WP_001292994.1 cytosol nonspecific dipeptidase -
QDX05_RS18410 (3706132) 3706132..3706653 - 522 Protein_3602 peptide chain release factor H -
QDX05_RS18415 (3706649) 3706649..3706855 - 207 Protein_3603 RtcB family protein -
QDX05_RS18420 (3707172) 3707172..3707624 - 453 WP_001059892.1 GNAT family N-acetyltransferase -
QDX05_RS18425 (3707634) 3707634..3708032 - 399 WP_001263489.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QDX05_RS18430 (3708035) 3708035..3708328 - 294 WP_000554758.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QDX05_RS18435 (3708380) 3708380..3709435 - 1056 WP_001226164.1 DNA polymerase IV -
QDX05_RS18440 (3709506) 3709506..3710291 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QDX05_RS18445 (3710263) 3710263..3711975 + 1713 Protein_3609 flagellar biosynthesis protein FlhA -
QDX05_RS18450 (3712199) 3712199..3712696 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15487.84 Da        Isoelectric Point: 7.4215

>T278248 WP_001263489.1 NZ_CP122929:c3708032-3707634 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT278248 WP_000554758.1 NZ_CP122929:c3708328-3708035 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090J8B1

Antitoxin

Source ID Structure
AlphaFold DB S1QAE3

References