Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1828654..1829156 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8E0FJZ4
Locus tag QDX05_RS08925 Protein ID WP_000767833.1
Coordinates 1828902..1829156 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QDX05_RS08920 Protein ID WP_001259255.1
Coordinates 1828654..1828905 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS08895 (1823832) 1823832..1824899 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDX05_RS08900 (1824899) 1824899..1825969 - 1071 WP_000108940.1 histidinol-phosphate transaminase -
QDX05_RS08905 (1825972) 1825972..1827270 - 1299 WP_049290931.1 histidinol dehydrogenase -
QDX05_RS08910 (1827276) 1827276..1828175 - 900 WP_000131756.1 ATP phosphoribosyltransferase -
QDX05_RS08915 (1828321) 1828321..1828371 - 51 WP_001364200.1 his operon leader peptide -
QDX05_RS08920 (1828654) 1828654..1828905 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDX05_RS08925 (1828902) 1828902..1829156 + 255 WP_000767833.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDX05_RS08930 (1829239) 1829239..1830063 + 825 WP_000754758.1 SDR family oxidoreductase -
QDX05_RS08935 (1830109) 1830109..1831038 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDX05_RS08940 (1831252) 1831252..1831314 + 63 WP_010723108.1 membrane protein YoeI -
QDX05_RS08945 (1831304) 1831304..1832662 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDX05_RS08950 (1832841) 1832841..1833899 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
QDX05_RS08955 (1833913) 1833913..1834140 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10173.54 Da        Isoelectric Point: 8.0353

>T278238 WP_000767833.1 NZ_CP122929:1828902-1829156 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT278238 WP_001259255.1 NZ_CP122929:1828654-1828905 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References