Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 649013..649740 Replicon chromosome
Accession NZ_CP122929
Organism Escherichia coli strain ETEC1702

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag QDX05_RS03185 Protein ID WP_000550189.1
Coordinates 649013..649327 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX05_RS03190 Protein ID WP_000560266.1
Coordinates 649324..649740 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX05_RS03165 (645179) 645179..646165 - 987 WP_023281494.1 Gfo/Idh/MocA family oxidoreductase -
QDX05_RS03170 (646244) 646244..646927 - 684 WP_001183042.1 vancomycin high temperature exclusion protein -
QDX05_RS03175 (647005) 647005..647508 - 504 WP_001295542.1 M48 family metallopeptidase -
QDX05_RS03180 (647593) 647593..648729 + 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
QDX05_RS03185 (649013) 649013..649327 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
QDX05_RS03190 (649324) 649324..649740 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
QDX05_RS03195 (649785) 649785..651803 - 2019 WP_049253702.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
QDX05_RS03200 (652229) 652229..654580 - 2352 WP_024238710.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T278234 WP_000550189.1 NZ_CP122929:649013-649327 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT278234 WP_000560266.1 NZ_CP122929:649324-649740 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References