Detailed information of TA system TA278229

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 38328..38744
• Replicon: plasmid unnamed4
• Accession: NZ_CP122927
• Organism: Escherichia coli strain ETEC1703

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QDX14_RS27260
• Protein ID: WP_247141765.1
• Coordinates: 38328..38450 (-)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	38535..38744 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDX14_RS27225	33648..33860	+	213	WP_032084501.1	hypothetical protein	-
QDX14_RS27230	33982..35049	-	1068	Protein_41	IS66-like element ISCro1 family transposase	-
QDX14_RS27235	35145..35492	-	348	WP_213833996.1	IS66 family insertion sequence element accessory protein TnpB	-
QDX14_RS27240	35492..35830	-	339	Protein_43	transposase	-
QDX14_RS27245	35912..36277	+	366	WP_000091308.1	hypothetical protein	-
QDX14_RS27250	36277..37464	+	1188	WP_000937592.1	IS91 family transposase	-
QDX14_RS27255	37654..37971	-	318	Protein_46	IS66 family insertion sequence element accessory protein TnpB	-
QDX14_RS27260	38328..38450	-	123	WP_247141765.1	Hok/Gef family protein	Toxin
QDX14_RS27265	38395..38547	-	153	Protein_48	DUF5431 family protein	-
-	38535..38744	+	210	-	-	Antitoxin
-	38535..38747	-	213	NuclAT_0	-	-
-	38535..38747	-	213	NuclAT_0	-	-
-	38535..38747	-	213	NuclAT_0	-	-
-	38535..38747	-	213	NuclAT_0	-	-
QDX14_RS27270	38696..39010	-	315	WP_089637073.1	theronine dehydrogenase	-
QDX14_RS27275	39007..39726	-	720	WP_032085152.1	plasmid SOS inhibition protein A	-
QDX14_RS27280	39723..40157	-	435	Protein_51	conjugation system SOS inhibitor PsiB	-
QDX14_RS27285	40212..42170	-	1959	WP_089637074.1	ParB/RepB/Spo0J family partition protein	-
QDX14_RS27290	42236..42469	-	234	WP_032085150.1	DUF905 family protein	-
QDX14_RS27295	42527..43060	-	534	WP_032085149.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	hlyD	1..107634	107634

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-35)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4562.36 Da
• Isoelectric Point: 8.2774

>T278229 WP_247141765.1 NZ_CP122927:c38450-38328 [Escherichia coli]
IVCCTLLIFTHLTRNRLCEVRLKDGYREVTATMAYESGGK

Nucleotide

• Length: 123 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT278229 NZ_CP122927:38535-38744 [Escherichia coli]
GTGGACTAGACATGCAGAGGCCTCGTGGGTTAATGAAAATTAACTACGGGGCTTTTGTCCTTCTGCCACACGACAGGATA
ACAAACCACCTTCACGTCATGAGGCAGAAAGCCTCAAGCGCCGGGCACATCATAGCCCATATACCTGCACGCTGACCACA
TTCACTTTCCCTGAAAATAATCCGGTCGTTCAGCCAGTTCACGGGCAATC

Structures

Antitoxin