Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4080038..4080579 Replicon chromosome
Accession NZ_CP122923
Organism Escherichia coli strain ETEC1703

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag QDX14_RS20630 Protein ID WP_000615980.1
Coordinates 4080301..4080579 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag QDX14_RS20625 Protein ID WP_000729707.1
Coordinates 4080038..4080298 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX14_RS20605 (4075704) 4075704..4076489 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
QDX14_RS20610 (4076461) 4076461..4078173 + 1713 Protein_4031 flagellar biosynthesis protein FlhA -
QDX14_RS20615 (4078406) 4078406..4078903 - 498 WP_000006245.1 REP-associated tyrosine transposase RayT -
QDX14_RS20620 (4079079) 4079079..4079852 - 774 WP_000543885.1 C40 family peptidase -
QDX14_RS20625 (4080038) 4080038..4080298 + 261 WP_000729707.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDX14_RS20630 (4080301) 4080301..4080579 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDX14_RS20635 (4080735) 4080735..4081475 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDX14_RS20640 (4081446) 4081446..4082213 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDX14_RS20645 (4082419) 4082419..4082997 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T278218 WP_000615980.1 NZ_CP122923:4080301-4080579 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9421.80 Da        Isoelectric Point: 5.0758

>AT278218 WP_000729707.1 NZ_CP122923:4080038-4080298 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKTKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure

References