Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4012043..4012584 Replicon chromosome
Accession NZ_CP122880
Organism Escherichia coli strain ETEC1716

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QDX09_RS20165 Protein ID WP_000615983.1
Coordinates 4012306..4012584 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QDX09_RS20160 Protein ID WP_000729703.1
Coordinates 4012043..4012303 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX09_RS20140 (4007718) 4007718..4008503 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
QDX09_RS20145 (4008475) 4008475..4010187 + 1713 Protein_3944 flagellar biosynthesis protein FlhA -
QDX09_RS20150 (4010411) 4010411..4010908 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
QDX09_RS20155 (4011084) 4011084..4011833 - 750 WP_000056849.1 C40 family peptidase -
QDX09_RS20160 (4012043) 4012043..4012303 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDX09_RS20165 (4012306) 4012306..4012584 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDX09_RS20170 (4012740) 4012740..4013480 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDX09_RS20175 (4013451) 4013451..4014218 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDX09_RS20180 (4014424) 4014424..4015002 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR / clpV/tssH / tssA / tssA / hcp1/tssD1 4005845..4043876 38031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T278192 WP_000615983.1 NZ_CP122880:4012306-4012584 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT278192 WP_000729703.1 NZ_CP122880:4012043-4012303 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
PDB 4Q2U
AlphaFold DB A0A5F1F716

References