Detailed information of TA system TA278172

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 68994..69410
• Replicon: plasmid unnamed2
• Accession: NZ_CP122878
• Organism: Escherichia coli strain ETEC1717

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QDX11_RS26290
• Protein ID: WP_247141765.1
• Coordinates: 69288..69410 (+)
• Length: 41 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	68994..69203 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDX11_RS26255	64678..65211	+	534	WP_032085149.1	single-stranded DNA-binding protein	-
QDX11_RS26260	65269..65502	+	234	WP_032085150.1	DUF905 family protein	-
QDX11_RS26265	65568..67526	+	1959	WP_089637074.1	ParB/RepB/Spo0J family partition protein	-
QDX11_RS26270	67581..68015	+	435	Protein_75	conjugation system SOS inhibitor PsiB	-
QDX11_RS26275	68012..68731	+	720	WP_032085152.1	plasmid SOS inhibition protein A	-
QDX11_RS26280	68728..69042	+	315	WP_089637073.1	theronine dehydrogenase	-
-	68991..69203	+	213	NuclAT_0	-	-
-	68991..69203	+	213	NuclAT_0	-	-
-	68991..69203	+	213	NuclAT_0	-	-
-	68991..69203	+	213	NuclAT_0	-	-
-	68994..69203	-	210	-	-	Antitoxin
QDX11_RS26285	69191..69343	+	153	Protein_78	DUF5431 family protein	-
QDX11_RS26290	69288..69410	+	123	WP_247141765.1	Hok/Gef family protein	Toxin
QDX11_RS26295	69767..70417	+	651	WP_000993931.1	IS66-like element accessory protein TnpA	-
QDX11_RS26300	70417..70764	+	348	WP_213833996.1	IS66 family insertion sequence element accessory protein TnpB	-
QDX11_RS26305	70860..71927	+	1068	Protein_82	IS66-like element ISCro1 family transposase	-
QDX11_RS26310	72049..72261	-	213	WP_032084501.1	hypothetical protein	-
QDX11_RS26315	72394..72954	-	561	WP_001523482.1	fertility inhibition protein FinO	-
QDX11_RS26320	73009..73755	-	747	WP_001523483.1	conjugal transfer pilus acetylase TraX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..102368	102368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-35)

Sequences

Toxin

Protein

• Length: 41 a.a.
• Molecular weight: 4562.36 Da
• Isoelectric Point: 8.2774

>T278172 WP_247141765.1 NZ_CP122878:69288-69410 [Escherichia coli]
IVCCTLLIFTHLTRNRLCEVRLKDGYREVTATMAYESGGK

Nucleotide

• Length: 123 bp

Antitoxin

Nucleotide

• Length: 210 bp

>AT278172 NZ_CP122878:c69203-68994 [Escherichia coli]
GTGGACTAGACATGCAGAGGCCTCGTGGGTTAATGAAAATTAACTACGGGGCTTTTGTCCTTCTGCCACACGACAGGATA
ACAAACCACCTTCACGTCATGAGGCAGAAAGCCTCAAGCGCCGGGCACATCATAGCCCATATACCTGCACGCTGACCACA
TTCACTTTCCCTGAAAATAATCCGGTCGTTCAGCCAGTTCACGGGCAATC

Structures

Antitoxin