Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4063639..4064180 Replicon chromosome
Accession NZ_CP122876
Organism Escherichia coli strain ETEC1717

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag QDX11_RS20485 Protein ID WP_000615980.1
Coordinates 4063902..4064180 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag QDX11_RS20480 Protein ID WP_000729707.1
Coordinates 4063639..4063899 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX11_RS20460 (4059305) 4059305..4060090 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
QDX11_RS20465 (4060062) 4060062..4061774 + 1713 Protein_4002 flagellar biosynthesis protein FlhA -
QDX11_RS20470 (4062007) 4062007..4062504 - 498 WP_000006245.1 REP-associated tyrosine transposase RayT -
QDX11_RS20475 (4062680) 4062680..4063453 - 774 WP_000543885.1 C40 family peptidase -
QDX11_RS20480 (4063639) 4063639..4063899 + 261 WP_000729707.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDX11_RS20485 (4063902) 4063902..4064180 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDX11_RS20490 (4064336) 4064336..4065076 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDX11_RS20495 (4065047) 4065047..4065814 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDX11_RS20500 (4066020) 4066020..4066598 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4022915..4065076 42161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T278165 WP_000615980.1 NZ_CP122876:4063902-4064180 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9421.80 Da        Isoelectric Point: 5.0758

>AT278165 WP_000729707.1 NZ_CP122876:4063639-4063899 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKTKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure

References