278127

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4565520..4566122 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDX04_RS22140 Protein ID WP_000897305.1
Coordinates 4565811..4566122 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX04_RS22135 Protein ID WP_000356397.1
Coordinates 4565520..4565810 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS22110 (4561446) 4561446..4562348 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDX04_RS22115 (4562345) 4562345..4562980 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDX04_RS22120 (4562977) 4562977..4563906 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDX04_RS22125 (4564236) 4564236..4564478 - 243 WP_001086388.1 protein YiiF -
QDX04_RS22130 (4564697) 4564697..4564915 - 219 WP_001297075.1 CopG family transcriptional regulator -
QDX04_RS22135 (4565520) 4565520..4565810 - 291 WP_000356397.1 NadS family protein Antitoxin
QDX04_RS22140 (4565811) 4565811..4566122 - 312 WP_000897305.1 hypothetical protein Toxin
QDX04_RS22145 (4566351) 4566351..4567259 + 909 WP_001162704.1 alpha/beta hydrolase -
QDX04_RS22150 (4567323) 4567323..4568264 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDX04_RS22155 (4568309) 4568309..4568746 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QDX04_RS22160 (4568743) 4568743..4569615 - 873 WP_088555649.1 virulence factor BrkB family protein -
QDX04_RS22165 (4569609) 4569609..4570208 - 600 WP_001295269.1 glucose-1-phosphatase -
QDX04_RS22170 (4570307) 4570307..4571092 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278127 WP_000897305.1 NZ_CP122868:c4566122-4565811 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278127 WP_000356397.1 NZ_CP122868:c4565810-4565520 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References