278123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3674588..3675129 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QDX04_RS17840 Protein ID WP_000615976.1
Coordinates 3674851..3675129 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QDX04_RS17835 Protein ID WP_000729704.1
Coordinates 3674588..3674848 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS17810 (3669624) 3669624..3670763 + 1140 WP_097447642.1 flagellar type III secretion system protein FlhB -
QDX04_RS17815 (3670747) 3670747..3672840 + 2094 WP_282843238.1 flagellar biosynthesis protein FlhA -
QDX04_RS17820 (3672945) 3672945..3673223 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QDX04_RS17825 (3673216) 3673216..3673572 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
QDX04_RS17830 (3673629) 3673629..3674402 - 774 WP_000543899.1 C40 family peptidase -
QDX04_RS17835 (3674588) 3674588..3674848 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDX04_RS17840 (3674851) 3674851..3675129 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDX04_RS17845 (3675285) 3675285..3676025 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDX04_RS17850 (3675996) 3675996..3676763 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDX04_RS17855 (3676969) 3676969..3677547 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T278123 WP_000615976.1 NZ_CP122868:3674851-3675129 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT278123 WP_000729704.1 NZ_CP122868:3674588-3674848 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References