278110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 618569..619368 Replicon chromosome
Accession NZ_CP122868
Organism Escherichia coli strain ETEC1721

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag QDX04_RS03050 Protein ID WP_000347267.1
Coordinates 618569..619033 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDX04_RS03055 Protein ID WP_001307405.1
Coordinates 619033..619368 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX04_RS03020 (613570) 613570..614004 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDX04_RS03025 (614022) 614022..614900 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
QDX04_RS03030 (614890) 614890..615669 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDX04_RS03035 (615680) 615680..616153 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDX04_RS03040 (616176) 616176..617456 - 1281 WP_097447699.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDX04_RS03045 (617705) 617705..618514 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
QDX04_RS03050 (618569) 618569..619033 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDX04_RS03055 (619033) 619033..619368 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDX04_RS03060 (619517) 619517..621088 - 1572 WP_001273741.1 galactarate dehydratase -
QDX04_RS03065 (621463) 621463..622797 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDX04_RS03070 (622813) 622813..623583 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 618569..630023 11454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T278110 WP_000347267.1 NZ_CP122868:c619033-618569 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278110 WP_001307405.1 NZ_CP122868:c619368-619033 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References