278085

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1806046..1806548 Replicon chromosome
Accession NZ_CP122859
Organism Escherichia coli strain ETEC1720

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag QDY31_RS08785 Protein ID WP_000767820.1
Coordinates 1806294..1806548 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QDY31_RS08780 Protein ID WP_001259255.1
Coordinates 1806046..1806297 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY31_RS08755 (1801223) 1801223..1802290 - 1068 WP_072668050.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QDY31_RS08760 (1802290) 1802290..1803360 - 1071 WP_000108928.1 histidinol-phosphate transaminase -
QDY31_RS08765 (1803357) 1803357..1804661 - 1305 WP_000009586.1 histidinol dehydrogenase -
QDY31_RS08770 (1804667) 1804667..1805566 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QDY31_RS08775 (1805712) 1805712..1805762 - 51 WP_001364200.1 his operon leader peptide -
QDY31_RS08780 (1806046) 1806046..1806297 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QDY31_RS08785 (1806294) 1806294..1806548 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QDY31_RS08790 (1806631) 1806631..1807455 + 825 WP_000754756.1 SDR family oxidoreductase -
QDY31_RS08795 (1807501) 1807501..1808430 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
QDY31_RS08800 (1808644) 1808644..1808706 + 63 WP_010723108.1 membrane protein YoeI -
QDY31_RS08805 (1808696) 1808696..1810054 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QDY31_RS08810 (1810233) 1810233..1811291 + 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
QDY31_RS08815 (1811305) 1811305..1811532 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T278085 WP_000767820.1 NZ_CP122859:1806294-1806548 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT278085 WP_001259255.1 NZ_CP122859:1806046-1806297 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References