Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 584051..584850 Replicon chromosome
Accession NZ_CP122859
Organism Escherichia coli strain ETEC1720

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag QDY31_RS02885 Protein ID WP_000347273.1
Coordinates 584051..584515 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDY31_RS02890 Protein ID WP_001307405.1
Coordinates 584515..584850 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY31_RS02855 (579052) 579052..579486 - 435 WP_000948842.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDY31_RS02860 (579504) 579504..580382 - 879 WP_094314169.1 PTS N-acetylgalactosamine transporter subunit IID -
QDY31_RS02865 (580372) 580372..581151 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDY31_RS02870 (581162) 581162..581635 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDY31_RS02875 (581658) 581658..582938 - 1281 WP_196011018.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDY31_RS02880 (583187) 583187..583996 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QDY31_RS02885 (584051) 584051..584515 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDY31_RS02890 (584515) 584515..584850 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDY31_RS02895 (584999) 584999..586570 - 1572 WP_001273753.1 galactarate dehydratase -
QDY31_RS02900 (586945) 586945..588279 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDY31_RS02905 (588295) 588295..589065 + 771 WP_196011017.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T278079 WP_000347273.1 NZ_CP122859:c584515-584051 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278079 WP_001307405.1 NZ_CP122859:c584850-584515 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References