Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3702616..3703310 Replicon chromosome
Accession NZ_CP122844
Organism Escherichia coli strain ETEC1722

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag QDX00_RS18180 Protein ID WP_001263493.1
Coordinates 3702616..3703014 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag QDX00_RS18185 Protein ID WP_000554757.1
Coordinates 3703017..3703310 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (3698276) 3698276..3698356 - 81 NuclAT_11 - -
- (3698276) 3698276..3698356 - 81 NuclAT_11 - -
- (3698276) 3698276..3698356 - 81 NuclAT_11 - -
- (3698276) 3698276..3698356 - 81 NuclAT_11 - -
QDX00_RS18150 (3697616) 3697616..3698860 - 1245 WP_000189541.1 esterase FrsA -
QDX00_RS18155 (3698952) 3698952..3699410 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
QDX00_RS18160 (3699671) 3699671..3701128 + 1458 WP_001293003.1 cytosol nonspecific dipeptidase -
QDX00_RS18165 (3701185) 3701185..3701706 - 522 Protein_3556 peptide chain release factor H -
QDX00_RS18170 (3701705) 3701705..3701908 - 204 Protein_3557 RtcB family protein -
QDX00_RS18175 (3702154) 3702154..3702606 - 453 WP_001059847.1 GNAT family N-acetyltransferase -
QDX00_RS18180 (3702616) 3702616..3703014 - 399 WP_001263493.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QDX00_RS18185 (3703017) 3703017..3703310 - 294 WP_000554757.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QDX00_RS18190 (3703362) 3703362..3704417 - 1056 WP_001226164.1 DNA polymerase IV -
QDX00_RS18195 (3704488) 3704488..3705273 - 786 WP_000207564.1 putative lateral flagellar export/assembly protein LafU -
QDX00_RS18200 (3705245) 3705245..3706957 + 1713 Protein_3563 flagellar biosynthesis protein FlhA -
QDX00_RS18205 (3707181) 3707181..3707678 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T278065 WP_001263493.1 NZ_CP122844:c3703014-3702616 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT278065 WP_000554757.1 NZ_CP122844:c3703310-3703017 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EXB8

Antitoxin

Source ID Structure
AlphaFold DB S1FJN6

References