Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4761950..4762552 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QDW97_RS23125 Protein ID WP_000897305.1
Coordinates 4762241..4762552 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDW97_RS23120 Protein ID WP_000356397.1
Coordinates 4761950..4762240 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS23095 (4757876) 4757876..4758778 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QDW97_RS23100 (4758775) 4758775..4759410 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QDW97_RS23105 (4759407) 4759407..4760336 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QDW97_RS23110 (4760666) 4760666..4760908 - 243 WP_001086388.1 protein YiiF -
QDW97_RS23115 (4761127) 4761127..4761345 - 219 WP_001295676.1 CopG family transcriptional regulator -
QDW97_RS23120 (4761950) 4761950..4762240 - 291 WP_000356397.1 NadS family protein Antitoxin
QDW97_RS23125 (4762241) 4762241..4762552 - 312 WP_000897305.1 hypothetical protein Toxin
QDW97_RS23130 (4762781) 4762781..4763689 + 909 WP_282843660.1 alpha/beta hydrolase -
QDW97_RS23135 (4763753) 4763753..4764694 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QDW97_RS23140 (4764739) 4764739..4765176 - 438 WP_094105341.1 D-aminoacyl-tRNA deacylase -
QDW97_RS23145 (4765173) 4765173..4766045 - 873 WP_000920762.1 virulence factor BrkB family protein -
QDW97_RS23150 (4766039) 4766039..4766638 - 600 WP_001315111.1 glucose-1-phosphatase -
QDW97_RS23155 (4766737) 4766737..4767522 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T278035 WP_000897305.1 NZ_CP122837:c4762552-4762241 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT278035 WP_000356397.1 NZ_CP122837:c4762240-4761950 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References