Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3821844..3822385 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag QDW97_RS18590 Protein ID WP_000615976.1
Coordinates 3822107..3822385 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag QDW97_RS18585 Protein ID WP_000729704.1
Coordinates 3821844..3822104 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS18560 (3817627) 3817627..3818412 - 786 WP_000207590.1 putative lateral flagellar export/assembly protein LafU -
QDW97_RS18565 (3818384) 3818384..3820096 + 1713 Protein_3637 flagellar biosynthesis protein FlhA -
QDW97_RS18570 (3820201) 3820201..3820479 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
QDW97_RS18575 (3820472) 3820472..3820828 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
QDW97_RS18580 (3820885) 3820885..3821658 - 774 WP_000543895.1 C40 family peptidase -
QDW97_RS18585 (3821844) 3821844..3822104 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDW97_RS18590 (3822107) 3822107..3822385 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDW97_RS18595 (3822541) 3822541..3823281 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDW97_RS18600 (3823252) 3823252..3824019 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDW97_RS18605 (3824225) 3824225..3824803 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA / rhs/PAAR 3820472..3839022 18550


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T278033 WP_000615976.1 NZ_CP122837:3822107-3822385 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT278033 WP_000729704.1 NZ_CP122837:3821844-3822104 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References