Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 646616..647415 Replicon chromosome
Accession NZ_CP122837
Organism Escherichia coli strain ETEC1729

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag QDW97_RS03210 Protein ID WP_000347267.1
Coordinates 646616..647080 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QDW97_RS03215 Protein ID WP_001307405.1
Coordinates 647080..647415 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW97_RS03180 (641617) 641617..642051 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QDW97_RS03185 (642069) 642069..642947 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
QDW97_RS03190 (642937) 642937..643716 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QDW97_RS03195 (643727) 643727..644200 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
QDW97_RS03200 (644223) 644223..645503 - 1281 WP_000681947.1 tagatose-bisphosphate aldolase subunit KbaZ -
QDW97_RS03205 (645752) 645752..646561 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
QDW97_RS03210 (646616) 646616..647080 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QDW97_RS03215 (647080) 647080..647415 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QDW97_RS03220 (647564) 647564..649135 - 1572 WP_001273741.1 galactarate dehydratase -
QDW97_RS03225 (649510) 649510..650844 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
QDW97_RS03230 (650860) 650860..651630 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T278021 WP_000347267.1 NZ_CP122837:c647080-646616 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT278021 WP_001307405.1 NZ_CP122837:c647415-647080 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References