Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5325062..5325474 Replicon chromosome
Accession NC_017906
Organism Escherichia coli Xuzhou21

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag CDCO157_RS27180 Protein ID WP_000132630.1
Coordinates 5325062..5325403 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5325398..5325474 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CDCO157_RS32890 5320630..5320830 + 201 WP_001310455.1 hypothetical protein -
CDCO157_RS27160 5321073..5322485 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
CDCO157_RS27165 5322662..5322826 + 165 WP_000394269.1 DUF1127 domain-containing protein -
CDCO157_RS27170 5322923..5323804 + 882 WP_001304007.1 DUF262 domain-containing protein -
CDCO157_RS30665 5323852..5325015 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
CDCO157_RS27180 5325062..5325403 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 5325398..5325474 + 77 NuclAT_13 - Antitoxin
- 5325398..5325474 + 77 NuclAT_13 - Antitoxin
- 5325398..5325474 + 77 NuclAT_13 - Antitoxin
- 5325398..5325474 + 77 NuclAT_13 - Antitoxin
- 5325398..5325474 + 77 NuclAT_14 - Antitoxin
- 5325398..5325474 + 77 NuclAT_14 - Antitoxin
- 5325398..5325474 + 77 NuclAT_14 - Antitoxin
- 5325398..5325474 + 77 NuclAT_14 - Antitoxin
CDCO157_RS27185 5325624..5327378 - 1755 WP_000110082.1 restriction endonuclease subunit S -
CDCO157_RS27190 5327378..5328847 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5314555..5333276 18721


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T27799 WP_000132630.1 NC_017906:c5325403-5325062 [Escherichia coli Xuzhou21]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T27799 NC_017906:c5325403-5325062 [Escherichia coli Xuzhou21]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT27799 NC_017906:5325398-5325474 [Escherichia coli Xuzhou21]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References