Detailed information of TA system TA277986

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 72795..73208
• Replicon: plasmid unnamed6
• Accession: NZ_CP122829
• Organism: Escherichia coli strain ETEC1732

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QDX01_RS28025
• Protein ID: WP_096937776.1
• Coordinates: 73083..73208 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	72795..73006 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDX01_RS27990 (69080)	69080..69514	+	435	WP_000845915.1	conjugation system SOS inhibitor PsiB	-
QDX01_RS27995 (69511)	69511..70267	+	757	Protein_71	plasmid SOS inhibition protein A	-
QDX01_RS28000 (70349)	70349..70774	+	426	WP_000422741.1	transposase	-
QDX01_RS28005 (70771)	70771..71121	+	351	WP_000624722.1	IS66 family insertion sequence element accessory protein TnpB	-
QDX01_RS28010 (71152)	71152..72765	+	1614	WP_282835484.1	IS66-like element ISEc23 family transposase	-
QDX01_RS28015 (72752)	72752..72970	-	219	WP_282835486.1	hypothetical protein	-
- (72939)	72939..73004	+	66	NuclAT_1	-	-
- (72939)	72939..73004	-	66	NuclAT_0	-	-
- (72792)	72792..73006	+	215	NuclAT_0	-	-
- (72792)	72792..73006	+	215	NuclAT_0	-	-
- (72792)	72792..73006	+	215	NuclAT_0	-	-
- (72792)	72792..73006	+	215	NuclAT_0	-	-
- (72795)	72795..73006	-	212	NuclAT_0	-	Antitoxin
QDX01_RS28020 (72992)	72992..73141	+	150	Protein_76	plasmid maintenance protein Mok	-
QDX01_RS28025 (73083)	73083..73208	+	126	WP_096937776.1	type I toxin-antitoxin system Hok family toxin	Toxin
QDX01_RS28030 (73553)	73553..75124	-	1572	WP_000381443.1	IS66 family transposase	-
QDX01_RS28035 (75144)	75144..75491	-	348	WP_000624618.1	IS66 family insertion sequence element accessory protein TnpB	-
QDX01_RS28040 (75491)	75491..76141	-	651	WP_000993956.1	IS66-like element accessory protein TnpA	-
QDX01_RS28045 (76227)	76227..76488	-	262	Protein_81	hypothetical protein	-
QDX01_RS28050 (76555)	76555..76731	+	177	Protein_82	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4806.72 Da
• Isoelectric Point: 8.4890

>T277986 WP_096937776.1 NZ_CP122829:73083-73208 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 212 bp

>AT277986 NZ_CP122829:c73006-72795 [Escherichia coli]
ATGTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTTTCTGCCACACA
ACACGGCAACAAACCACCTTCACGTCATGAGGCAGAAAGCCTCAAGCGCCGGGCACATCATAGCCCATATACCTGCACGC
TGACCACACTCACTTTCCCTGAAAATAATCTGGTCGTTCAGCCAGTTCACGG

Structures

Antitoxin