Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 28002..28713 Replicon plasmid unnamed5
Accession NZ_CP122828
Organism Escherichia coli strain ETEC1732

Toxin (Protein)


Gene name higB Uniprot ID I2UJZ0
Locus tag QDX01_RS27295 Protein ID WP_000162415.1
Coordinates 28411..28713 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX01_RS27290 Protein ID WP_000806445.1
Coordinates 28002..28340 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX01_RS27255 (QDX01_27255) 23159..23551 - 393 WP_000824758.1 hypothetical protein -
QDX01_RS27260 (QDX01_27260) 23572..24180 - 609 WP_282835468.1 hypothetical protein -
QDX01_RS27265 (QDX01_27265) 24464..25117 + 654 WP_000410952.1 hypothetical protein -
QDX01_RS27270 (QDX01_27270) 25446..25775 + 330 WP_000542383.1 hypothetical protein -
QDX01_RS27275 (QDX01_27275) 25768..26961 + 1194 WP_001112633.1 hypothetical protein -
QDX01_RS27280 (QDX01_27280) 26995..27723 - 729 WP_000986754.1 hypothetical protein -
QDX01_RS27285 (QDX01_27285) 27760..27945 - 186 Protein_46 hypothetical protein -
QDX01_RS27290 (QDX01_27290) 28002..28340 - 339 WP_000806445.1 HigA family addiction module antitoxin Antitoxin
QDX01_RS27295 (QDX01_27295) 28411..28713 - 303 WP_000162415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX01_RS27300 (QDX01_27300) 28876..29667 + 792 WP_000532305.1 hypothetical protein -
QDX01_RS27305 (QDX01_27305) 29664..30431 + 768 WP_000203290.1 hypothetical protein -
QDX01_RS27310 (QDX01_27310) 30435..31415 + 981 WP_000046499.1 hypothetical protein -
QDX01_RS27315 (QDX01_27315) 31460..32065 + 606 WP_223699645.1 carbohydrate-binding domain-containing protein -
QDX01_RS27320 (QDX01_27320) 32125..33030 + 906 WP_282835469.1 recombination-associated protein RdgC -
QDX01_RS27325 (QDX01_27325) 33074..33694 + 621 WP_044862276.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90359 90359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11818.56 Da        Isoelectric Point: 9.8739

>T277985 WP_000162415.1 NZ_CP122828:c28713-28411 [Escherichia coli]
MTKKINIKDFRDAWLDDFFEFSTPHRKIPPDIHMTLSRKLDIINAATTCKDLRSPPGNRYEELSGKLNGYSSVRVNKQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13049.98 Da        Isoelectric Point: 6.4754

>AT277985 WP_000806445.1 NZ_CP122828:c28340-28002 [Escherichia coli]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRINTAEKFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A631VBQ3

Antitoxin

Source ID Structure

References