277974

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4151024..4151565 Replicon chromosome
Accession NZ_CP122823
Organism Escherichia coli strain ETEC1732

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag QDX01_RS21060 Protein ID WP_000615983.1
Coordinates 4151287..4151565 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q47150
Locus tag QDX01_RS21055 Protein ID WP_000729703.1
Coordinates 4151024..4151284 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX01_RS21035 (4146699) 4146699..4147484 - 786 WP_000207587.1 putative lateral flagellar export/assembly protein LafU -
QDX01_RS21040 (4147456) 4147456..4149168 + 1713 Protein_4120 flagellar biosynthesis protein FlhA -
QDX01_RS21045 (4149392) 4149392..4149889 - 498 Protein_4121 REP-associated tyrosine transposase RayT -
QDX01_RS21050 (4150065) 4150065..4150814 - 750 WP_024192679.1 C40 family peptidase -
QDX01_RS21055 (4151024) 4151024..4151284 + 261 WP_000729703.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
QDX01_RS21060 (4151287) 4151287..4151565 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
QDX01_RS21065 (4151721) 4151721..4152461 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
QDX01_RS21070 (4152432) 4152432..4153199 - 768 WP_000333380.1 class II glutamine amidotransferase -
QDX01_RS21075 (4153405) 4153405..4153983 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 4143865..4160107 16242


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T277974 WP_000615983.1 NZ_CP122823:4151287-4151565 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9405.80 Da        Isoelectric Point: 5.0758

>AT277974 WP_000729703.1 NZ_CP122823:4151024-4151284 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1F716

References