Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2730989..2731627 Replicon chromosome
Accession NZ_CP122823
Organism Escherichia coli strain ETEC1732

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDX01_RS13620 Protein ID WP_000813794.1
Coordinates 2731451..2731627 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDX01_RS13615 Protein ID WP_001270286.1
Coordinates 2730989..2731405 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX01_RS13595 (2726141) 2726141..2727082 - 942 WP_001251304.1 ABC transporter permease -
QDX01_RS13600 (2727083) 2727083..2728096 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDX01_RS13605 (2728114) 2728114..2729259 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDX01_RS13610 (2729504) 2729504..2730910 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QDX01_RS13615 (2730989) 2730989..2731405 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDX01_RS13620 (2731451) 2731451..2731627 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDX01_RS13625 (2731849) 2731849..2732079 + 231 WP_000494244.1 YncJ family protein -
QDX01_RS13630 (2732171) 2732171..2734132 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDX01_RS13635 (2734205) 2734205..2734741 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDX01_RS13640 (2734833) 2734833..2736005 + 1173 WP_001236264.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2736048..2737196 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277970 WP_000813794.1 NZ_CP122823:c2731627-2731451 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277970 WP_001270286.1 NZ_CP122823:c2731405-2730989 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References