Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 734522..735215 Replicon chromosome
Accession NZ_CP122816
Organism Escherichia coli strain ETEC1731

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QDY29_RS03615 Protein ID WP_000415584.1
Coordinates 734522..734818 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QDY29_RS03620 Protein ID WP_000650107.1
Coordinates 734820..735215 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY29_RS03585 (730197) 730197..730511 - 315 WP_000958598.1 putative quinol monooxygenase -
QDY29_RS03590 (730542) 730542..731123 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QDY29_RS03595 (731233) 731233..732582 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
QDY29_RS03600 (732579) 732579..733238 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
QDY29_RS03605 (733390) 733390..733782 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QDY29_RS03610 (733835) 733835..734317 + 483 WP_000183498.1 GyrI-like domain-containing protein -
QDY29_RS03615 (734522) 734522..734818 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QDY29_RS03620 (734820) 734820..735215 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QDY29_RS03625 (735348) 735348..736955 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
QDY29_RS03630 (737093) 737093..739351 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 722532..735215 12683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T277929 WP_000415584.1 NZ_CP122816:734522-734818 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT277929 WP_000650107.1 NZ_CP122816:734820-735215 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References