277925

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 70382..71093 Replicon plasmid unnamed8
Accession NZ_CP122809
Organism Escherichia coli strain ETEC1734

Toxin (Protein)


Gene name higB Uniprot ID I2UJZ0
Locus tag QDX84_RS28485 Protein ID WP_000162415.1
Coordinates 70382..70684 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QDX84_RS28490 Protein ID WP_000806445.1
Coordinates 70755..71093 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX84_RS28455 (QDX84_28455) 65401..66021 - 621 WP_044862276.1 hypothetical protein -
QDX84_RS28460 (QDX84_28460) 66065..66970 - 906 WP_282835469.1 recombination-associated protein RdgC -
QDX84_RS28465 (QDX84_28465) 67030..67635 - 606 WP_223699645.1 carbohydrate-binding domain-containing protein -
QDX84_RS28470 (QDX84_28470) 67680..68660 - 981 WP_000046499.1 hypothetical protein -
QDX84_RS28475 (QDX84_28475) 68664..69431 - 768 WP_000203290.1 hypothetical protein -
QDX84_RS28480 (QDX84_28480) 69428..70219 - 792 WP_000532305.1 hypothetical protein -
QDX84_RS28485 (QDX84_28485) 70382..70684 + 303 WP_000162415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDX84_RS28490 (QDX84_28490) 70755..71093 + 339 WP_000806445.1 HigA family addiction module antitoxin Antitoxin
QDX84_RS28495 (QDX84_28495) 71150..71335 + 186 Protein_77 hypothetical protein -
QDX84_RS28500 (QDX84_28500) 71372..72100 + 729 WP_000986754.1 hypothetical protein -
QDX84_RS28505 (QDX84_28505) 72134..73327 - 1194 WP_001112633.1 hypothetical protein -
QDX84_RS28510 (QDX84_28510) 73320..73649 - 330 WP_000542383.1 hypothetical protein -
QDX84_RS28515 (QDX84_28515) 73978..74631 - 654 WP_000410952.1 hypothetical protein -
QDX84_RS28520 (QDX84_28520) 74915..75523 + 609 WP_282835468.1 hypothetical protein -
QDX84_RS28525 (QDX84_28525) 75544..75936 + 393 WP_000824758.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90361 90361


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11818.56 Da        Isoelectric Point: 9.8739

>T277925 WP_000162415.1 NZ_CP122809:70382-70684 [Escherichia coli]
MTKKINIKDFRDAWLDDFFEFSTPHRKIPPDIHMTLSRKLDIINAATTCKDLRSPPGNRYEELSGKLNGYSSVRVNKQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13049.98 Da        Isoelectric Point: 6.4754

>AT277925 WP_000806445.1 NZ_CP122809:70755-71093 [Escherichia coli]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRINTAEKFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A631VBQ3

Antitoxin

Source ID Structure

References